USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: LMNA_HUMAN USC-OGP 2-DE database:  LMNA_HUMAN LMNA_HUMAN General information about the entry View entry in simple text format Entry name LMNA_HUMAN Primary accession number P02545 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Prelamin-A/C; Contains: RecName: Full=Lamin-A/C; AltName: Full=70 kDa lamin; AltName: Full=Renal carcinoma antigen NY-REN-32; Flags: Precursor;. Gene name Name=LMNA Synonyms=LMN1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1125: pI=6.92; Mw=75177 SPOT OGP-1132: pI=6.61; Mw=65162 SPOT OGP-1134: pI=6.89; Mw=63844 Cross-references UniProtKB/Swiss-Prot P02545; LMNA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name LMNA_HUMAN Primary accession number P02545 Secondary accession number(s) B4DI32 D3DVB0 D6RAQ3 E7EUI9 P02546 Q5I6Y4 Q5I6Y6 Q5TCJ2 Q5TCJ3 Q6UYC3 Q969I8 Q96JA2 Sequence was last modified on  March 20, 1987 (version 1) Annotations were last modified on  March 15, 2017 (version 227) Name and origin of the protein Description RecName: Full=Prelamin-A/C; Contains: RecName: Full=Lamin-A/C; AltName: Full=70 kDa lamin; AltName: Full=Renal carcinoma antigen NY-REN-32; Flags: Precursor; Gene name Name=LMNA Synonyms=LMN1 Encoded on Name=LMNA; Synonyms=LMN1 Keywords 3D-structure; Acetylation; Alternative splicing; Cardiomyopathy; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Congenital muscular dystrophy; Direct protein sequencing; Disease mutation; Emery-Dreifuss muscular dystrophy; Intermediate filament; Isopeptide bond; Limb-girdle muscular dystrophy; Lipoprotein; Methylation; Neurodegeneration; Neuropathy; Nucleus; Phosphoprotein; Polymorphism; Prenylation; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X03444; CAA27173.1; ALT_FRAME; mRNA EMBL X03445; CAA27174.1; -; mRNA EMBL M13451; AAA36164.1; -; mRNA EMBL M13452; AAA36160.1; -; mRNA EMBL AY847597; AAW32540.1; -; mRNA EMBL AY847595; AAW32538.1; -; mRNA EMBL AY357727; AAR29466.1; -; mRNA EMBL AK295390; BAG58344.1; -; mRNA EMBL AL135927; CAI15521.1; -; Genomic_DNA EMBL AL135927; CAI15522.1; -; Genomic_DNA EMBL AL355388; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AL356734; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471121; EAW52997.1; -; Genomic_DNA EMBL CH471121; EAW52999.1; -; Genomic_DNA EMBL BC000511; AAH00511.1; -; mRNA EMBL BC003162; AAH03162.1; -; mRNA EMBL BC014507; AAH14507.1; -; mRNA EMBL AF381029; AAK59326.1; -; mRNA CCDS CCDS1129.1; -. [P02545-1]; . CCDS CCDS1131.1; -. [P02545-2]; . CCDS CCDS58038.1; -. [P02545-4]; . CCDS CCDS72941.1; -. [P02545-6]; . PIR A02961; VEHULA; . PIR A02962; VEHULC; . RefSeq NP_001244303.1; NM_001257374.2. [P02545-4]; . RefSeq NP_001269553.1; NM_001282624.1; . RefSeq NP_001269554.1; NM_001282625.1. [P02545-2]; . RefSeq NP_001269555.1; NM_001282626.1. [P02545-6]; . RefSeq NP_005563.1; NM_005572.3. [P02545-2]; . RefSeq NP_733821.1; NM_170707.3. [P02545-1]; . RefSeq NP_733822.1; NM_170708.3. [P02545-3]; . UniGene Hs.594444; -; . UniGene Hs.706897; -; . UniGene Hs.733671; -; . PDB 1IFR; X-ray; 1.40 A; A=436-552 PDB 1IVT; NMR; -; A=428-549 PDB 1X8Y; X-ray; 2.20 A; A=305-387 PDB 2XV5; X-ray; 2.40 A; A/B=328-398 PDB 2YPT; X-ray; 3.80 A; F/G/H/I=661-664 PDB 3GEF; X-ray; 1.50 A; A/B/C/D=436-552 PDB 3V4Q; X-ray; 3.06 A; A=313-386 PDB 3V4W; X-ray; 3.70 A; A=313-386 PDB 3V5B; X-ray; 3.00 A; A=313-386 PDBsum 1IFR; -; . PDBsum 1IVT; -; . PDBsum 1X8Y; -; . PDBsum 2XV5; -; . PDBsum 2YPT; -; . PDBsum 3GEF; -; . PDBsum 3V4Q; -; . PDBsum 3V4W; -; . PDBsum 3V5B; -; . DisProt DP00716; -; . ProteinModelPortal P02545; -; . SMR P02545; -; . BioGrid 110186; 225; . DIP DIP-32948N; -; . DIP DIP-58162N; -; . IntAct P02545; 65; . MINT MINT-5003995; -; . STRING 9606.ENSP00000357283; -; . ChEMBL CHEMBL1293235; -; . iPTMnet P02545; -; . PhosphoSitePlus P02545; -; . SwissPalm P02545; -; . BioMuta LMNA; -; . DMDM 125962; -; . REPRODUCTION-2DPAGE IPI00021405; -; . REPRODUCTION-2DPAGE IPI00216952; -; . REPRODUCTION-2DPAGE P02545; -; . SWISS-2DPAGE P02545; -; . EPD P02545; -; . MaxQB P02545; -; . PaxDb P02545; -; . PeptideAtlas P02545; -; . PRIDE P02545; -; . TopDownProteomics P02545-1; -. [P02545-1]; . TopDownProteomics P02545-2; -. [P02545-2]; . TopDownProteomics P02545-4; -. [P02545-4]; . DNASU 4000; -; . Ensembl ENST00000347559; ENSP00000292304; ENSG00000160789. [P02545-3]; . Ensembl ENST00000368299; ENSP00000357282; ENSG00000160789. [P02545-6]; . Ensembl ENST00000368300; ENSP00000357283; ENSG00000160789. [P02545-1]; . Ensembl ENST00000368301; ENSP00000357284; ENSG00000160789. [P02545-2]; . Ensembl ENST00000448611; ENSP00000395597; ENSG00000160789. [P02545-4]; . Ensembl ENST00000473598; ENSP00000421821; ENSG00000160789. [P02545-5]; . GeneID 4000; -; . KEGG hsa:4000; -; . UCSC uc001fnf.3; human. [P02545-1]; . CTD 4000; -; . DisGeNET 4000; -; . GeneCards LMNA; -; . GeneReviews LMNA; -; . HGNC HGNC:6636; LMNA; . HPA CAB004022; -; . HPA HPA006660; -; . MalaCards LMNA; -; . MIM 115200; phenotype; . MIM 150330; gene; . MIM 151660; phenotype; . MIM 159001; phenotype; . MIM 176670; phenotype; . MIM 181350; phenotype; . MIM 212112; phenotype; . MIM 248370; phenotype; . MIM 275210; phenotype; . MIM 605588; phenotype; . MIM 610140; phenotype; . MIM 613205; phenotype; . MIM 616516; phenotype; . neXtProt NX_P02545; -; . OpenTargets ENSG00000160789; -; . Orphanet 79474; Atypical Werner syndrome; . Orphanet 280365; Autosomal codominant severe lipodystrophic laminopathy; . Orphanet 98853; Autosomal dominant Emery-Dreifuss muscular dystrophy; . Orphanet 264; Autosomal dominant limb-girdle muscular dystrophy type 1B; . Orphanet 98855; Autosomal recessive Emery-Dreifuss muscular dystrophy; . Orphanet 98856; Charcot-Marie-Tooth disease type 2B1; . Orphanet 157973; Congenital muscular dystrophy due to LMNA mutation; . Orphanet 2229; Dilated cardiomyopathy - hypergonadotropic hypogonadism; . Orphanet 300751; Familial dilated cardiomyopathy with conduction defect due to LMNA mutation; . Orphanet 293899; Familial isolated arrhythmogenic ventricular dysplasia; biventricular form; . Orphanet 293888; Familial isolated arrhythmogenic ventricular dysplasia; left dominant form; . Orphanet 293910; Familial isolated arrhythmogenic ventricular dysplasia; right dominant form; . Orphanet 2348; Familial partial lipodystrophy; Dunnigan type; . Orphanet 79084; Familial partial lipodystrophy; Kobberling type; . Orphanet 168796; Heart-hand syndrome; Slovenian type; . Orphanet 740; Hutchinson-Gilford progeria syndrome; . Orphanet 137871; Laminopathy type Decaudain-Vigouroux; . Orphanet 54260; Left ventricular noncompaction; . Orphanet 1662; Lethal restrictive dermopathy; . Orphanet 363618; LMNA-related cardiocutaneous progeria syndrome; . Orphanet 90153; Mandibuloacral dysplasia with type A lipodystrophy; . Orphanet 99706; Progeria-associated arthropathy; . PharmGKB PA231; -; . eggNOG KOG0977; Eukaryota; . eggNOG ENOG410Y2H6; LUCA; . GeneTree ENSGT00830000128282; -; . HOGENOM HOG000007711; -; . HOVERGEN HBG013015; -; . InParanoid P02545; -; . KO K12641; -; . OMA SHVSRHR; -; . OrthoDB EOG091G063B; -; . PhylomeDB P02545; -; . TreeFam TF101181; -; . Reactome R-HSA-1221632; Meiotic synapsis; . Reactome R-HSA-2993913; Clearance of Nuclear Envelope Membranes from Chromatin; . Reactome R-HSA-2995383; Initiation of Nuclear Envelope Reformation; . Reactome R-HSA-352238; Breakdown of the nuclear lamina; . Reactome R-HSA-381038; XBP1(S) activates chaperone genes; . Reactome R-HSA-4419969; Depolymerisation of the Nuclear Lamina; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; . SIGNOR P02545; -; . ChiTaRS LMNA; human; . EvolutionaryTrace P02545; -; . GeneWiki LMNA; -; . GenomeRNAi 4000; -; . PMAP-CutDB P02545; -; . PRO PR:P02545; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000160789; -; . CleanEx HS_LMNA; -; . ExpressionAtlas P02545; baseline and differential; . Genevisible P02545; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005882; C:intermediate filament; TAS:UniProtKB; . GO GO:0005638; C:lamin filament; TAS:UniProtKB; . GO GO:0005635; C:nuclear envelope; IDA:UniProtKB; . GO GO:0005652; C:nuclear lamina; TAS:UniProtKB; . GO GO:0031965; C:nuclear membrane; IDA:UniProtKB; . GO GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0005198; F:structural molecule activity; TAS:UniProtKB; . GO GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB; . GO GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; ISS:BHF-UCL; . GO GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome; . GO GO:0007077; P:mitotic nuclear envelope disassembly; TAS:Reactome; . GO GO:0007084; P:mitotic nuclear envelope reassembly; TAS:Reactome; . GO GO:0007517; P:muscle organ development; IMP:UniProtKB; . GO GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl; . GO GO:0072201; P:negative regulation of mesenchymal cell proliferation; IEA:Ensembl; . GO GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IEA:Ensembl; . GO GO:0090343; P:positive regulation of cell aging; IDA:UniProtKB; . GO GO:0034504; P:protein localization to nucleus; ISS:UniProtKB; . GO GO:0030334; P:regulation of cell migration; ISS:BHF-UCL; . GO GO:1900180; P:regulation of protein localization to nucleus; IEA:Ensembl; . GO GO:0035105; P:sterol regulatory element binding protein import into nucleus; IEA:Ensembl; . GO GO:0055015; P:ventricular cardiac muscle cell development; IEA:Ensembl; . Gene3D 2.60.40.1260; -; 1; . InterPro IPR001664; IF; . InterPro IPR018039; Intermediate_filament_CS; . InterPro IPR001322; Lamin_tail_dom; . PANTHER PTHR23239; PTHR23239; 1; . Pfam PF00038; Filament; 1; . Pfam PF00932; LTD; 1; . SMART SM01391; Filament; 1; . SUPFAM SSF74853; SSF74853; 1; . PROSITE PS00226; IF; 1; .

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